Eating up damaged lysosomes

Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy.

Ubiquitination functions as a signal to recruit autophagic machinery to damaged organelles and induce their clearance. Here, we report the characterization of FBXO27, a glycoprotein-specific F-box protein that is part of the SCF (SKP1/CUL1/F-box protein) ubiquitin ligase complex, and demonstrate that SCFFBXO27 ubiquitinates glycoproteins in damaged lysosomes to regulate autophagic machinery rec...

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury.

Diverse causes, including pathogenic invasion or the uptake of mineral crystals such as silica and monosodium urate (MSU), threaten cells with lysosomal rupture, which can lead to oxidative stress, inflammation, and apoptosis or necrosis. Here, we demonstrate that lysosomes are selectively sequestered by autophagy, when damaged by MSU, silica, or the lysosomotropic reagent L-Leucyl-L-leucine me...

Auotphagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

The Diagnostic Work-Up of Eating Disorders

Anorexia Nervosa (AN): Anorexia Nervosa is characterized by an enduring restriction of food intake resulting in low body weight and low body mass index (BMI). This may progress to cachexia. Accompanying symptoms are an irrational fear of weight gain, excessive exercise, distorted body image and menstrual dysfunction in women [2]. The prevalence of AN prevalence is estimated to be between 0.3 an...

Eating the competition speeds up invasions.

Many introduced species engage in intraguild predation (IGP), the consumption of species with which they compete for shared resources. While the factors influencing local persistence of IG predator and prey species are well-understood, using these factors to predict the invasion speed of an introduced IG predator has received less attention. Existing theory predicts that native competitors slow...